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About Us

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Mertens Lab

Neural Aging Laboratory
Department of Neurosciences
University of California San Diego

In the Neural Aging Lab, we reprogram human skin cells into brain cells to better understand age-related diseases. We apply both directly induced neurons (iNs) and induced pluripotent stem cell (iPSC) technologies to develop and learn from the next generation of human disease models.

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Research

OUR RESEARCH

"Patient-derived models for the human brain are both fascinating and useful. Centered around the actual patient, they can teach us about diseases of the brain."

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By combining our patient-centric approach with cellular neuroscience techniques and a passion for big data biology, the goal of our lab is to identify the molecular key players of human biological aging to point toward  new treatment strategies for neurological age-related neurodegenerative diseases.

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Joe Herdy et al. Cell Stem Cell. 2022

Old human neurons can enter a state of post-mitotic senescence, in which neurons secrete proinflamma-tory SASP factors that can trigger brain inflammation late in life, and particularly in Alzheimer's Disease.

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Team

TIMON STEIN

BSc student and tech in the lab, he is now looking for an MSc program...

LAURA WEIGL

BSc student 2022

OUR TEAM

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JEROME MERTENS

Jerome is Associate Professor at the Department of Neurosciences of UCSD, and Adjunct at the Salk Institute in La Jolla, CA. Before he was Assistant Professor at the University of Innsbruck in Austria. His research focus is to better understand the interface between the biology of aging and neurodegeneration. Jerome completed his PhD in the lab of Oliver Brüstle (University of Bonn) and Philipp Koch, and his postdoc in Rusty Gage’s lab. His work has been supported by grants and fellowships, including a K99/R00, a Marie Curie Fellowship, and an ERC Starting Grant.

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JESSICA LAGERWALL

Jessica is a third year PhD student in the Neural Aging Lab. She received her BSc in Molecular Biology and Biotechnology and her MSc in Genetics from Stellenbosch University in South Africa. During her MSc she spent 8 months at Lund University in Sweden where she was first introduced to the iN model by Karolina Pircs and Johan Jakobsson. Jessica is interested in what goes awry in the aging brain which then leads to disease. She is investigating this using genetics, cellular modelling and bioinformatic methods. In her free time Jessica likes hiking, mountain biking and trail running, and spending time with friends.

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Larissa is a postdoc in Jerome's lab, and her focus is on metabolic alterations in Alzheimer’s Disease. Her research has been supported by a L’Oréal Österreich/ÖUK/ÖAW and a Theodor Körner fellowship. Larissa received her BSc in Molecular Medicine from the Medical University of Innsbruck and her MSc in Biomedicine from Lund University in Sweden. She also actively collaborates with Angelo D'Alessandro's lab at UC Denver, and enjoys frequent research stays at the Salk Institute. In her free time, Larissa loves to spend her time outdoors in the mountains, going for hikes or paragliding, and enjoying a good beer.

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JOSEPH R. HERDY

Joe is PhD student in the Neuroscience graduate program at UC San Diego and a joint member of Mertens lab and the Gage lab at the Salk Institute. Joe received his BSc from the University of Alabama in Huntsville and his MSc from the University of Kentucky. Joe's research focuses on the induction of neuronal senescence during aging and neurodegenerative disease. Outside of the lab, Joe enjoys hiking, fishing, rock climbing and any other excuse to spend time outdoors.

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LUCIA ZHOU-YANG

Lucy is a graduate student in the lab. She earned her BSc in Health Biology and MSc in Biomedicine at Autónoma University Madrid. Her research in Madrid focussed on gene therapy using iPSC lung organoids, and iPSC modeling in Jun Yao's lab at Tsinghua University in Beijing. Lucy is interested in integrating fate reprogramming technologies with 3D cultures, and age-related diseases. She's always happy, smiley, loves socializing, and always open for any kind of group activities. 

 â™ªâ™ª Dale a tu cuerpo alegría Macarena

Que tu cuerpo es pa' darle alegría why cosa buena

Dale a tu cuerpo alegría, Macarena

Hey Macarena!!!!! ♫♫

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SOPHIE EICHHORNER

Sophie is a graduate student in the lab, who already did her BSc in Biology and MSc in Molecular Cell and Developmental Biology at the University of Innsbruck. She is especially interested in neuroscience and aging and developed a fascination in metabolic alterations in neurons that fall victim to age-related diseases. In her free time she enjoys horseback riding, reading and the occasional hike.

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OLIVER BORGOGNO

Oli is a graduate student in the lab. He received his BSc in Biology and his MSc in Molecular Biology at the University of Innsbruck. His study focuses on the molecular crosstalk between psychiatric disorders, accelerated aging, and Alzheimer’s disease. Therefore, he uses a hybrid approach consisting of a broad variety of different cell-culture techniques coupled with the subsequent bioinformatic  analysis. In his free time Oliver loves to boulder in- and outdoor as well as going on trail runs in the mountains. Since he is a nerd, special  interests of him are computers and 3D-printers.
As soon as he finishes his Master, Oliver wants to dig deeper into the possibilities Big Data Biology offer with

a particular focus on Neuroscience and Aging.

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Anna is a NGP grad student at UCSD

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LUKAS KARBACHER

Lukas is a graduate student with NGP at UCSD

ALUMNI

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​SILVIA PELUCCHI

Silvia was a Postdoc in the lab in Innsbruck, and is now a PI at University of Milano, and she is still considered a member of the Mertens lab at UCSD

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FLORIAN SCHOEN

Flo was the lab manager of our lab in Innsbruck. He completed his MSc in the lab and stayed in Austria and moved on to new exciting projects.

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DANIELA FRANTAL

Dani was a Research Assistant in the lab, and she just had a new addition to the family and is currently taking a break from work. 

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RAVI AGARWAL

Part-time research assistant supporting the lab in San Diego since a long time :)

-> Medical School at UC San Diego 

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PHILIPP BOUSSARD

MSc student 2020/2021

-> Humanmedizin, Uni Heidelberg

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ANNA SMALING

Anna is a completed her MSc in the lab. She now works for Oroboros Instruments

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BELLA ROHWEDER

 BSc student 2021

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JANINA KASPAR

MSc ERASMUS student 2020

-> MSc at University of Heidelberg (Moritz Mall lab)

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ALICE SANTAGOSTINO

BSc student 2020

-> MSc at University of Innsbruck

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TIM CIESIOLKA

BSc student 2019-2020

->  Roche Diagnostics

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STINA LAGERSTRÖM

Stina was a MSc student in the lab, and she is now back in Sweden working on her PhD research

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MATILDE IRACI

MSc student 2020/2021

-> PhD student, Helmholtz Munich

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ANNA DENGLER

Lab intern 2022

MolZEB University of Innsbruck.

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ISABELLA ANGELI

BSc student 2021

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FLORA KOGLER

BSc student 2020

-> BSc at University of Innsbruck

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LUKAS C. MAASS

BSc student 2019

->  Roche Diagnostics

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SANTIAGO ARDILES

Lab intern 2018-2019

-> MSc at Medical University Innsbruck

ALICE FOLTYNOVA

Post-MSc intern 2021/2022 -> Uni Prague, CZ

LORE HELLEMANS

BSc student 2020

LEA NAGELSCHMIED

BSc intern 2021

KATHARINA SCHULER

MSc intern 2022

JULIA-ANNA ULZ

MSc intern 2022

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Lena is a graduate student enrolled in the doctoral AGE_REG PhD program. Lena received her BSc in Molecular Medicine from the University of Erlangen-Nuremberg and her MSc in Molecular Sciences from the University of Lübeck in Germany. Before coming to Innsbruck, she joined Jerome for several research stays at the Salk Institute and worked at the drug discovery alliance and development partnership company Evotec. Lena is currently finishing her PhD thesis writing, and did not move with the lab to San Diego (yet).

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TAYLOR OZBUN

Taylor is an undergrad researcher in the lab.

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Annette is an undergrad researcher in the lab.

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Testimonials

PUBLICATIONS

’Increased Post-Mitotic Senescence in Aged Human Neurons is a Pathological Feature of Alzheimer’s Disease’

J. R. Herdy, L. Traxler, R.K. Agarwal, L. Karbacher, J.C.M. Schlachetzki, L. Boehnke, D. Zangwill, D. Galasko, C.K. Glass, J. Mertens# & F.H. Gage#. 

Cell Stem Cell, Dec 2022

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‘Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion’

L. Böhnke, L. Zhou-Yang, S. Pelucchi, F. Kogler, D. Frantal, F. Schön, S. Lagerström, O. Borgogno, J. Baltazar, J.R. Herdy, S. Kittel-Schneider, M. Defrancesco, and J. Mertens#.

Cellular Reprogramming, Jul 2022. 

 

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease’
L. Traxler, J.R. Herdy, D. Stefanoni, S. Eichhorner, S. Pelucchi, A. Szücs, A. Santagostino, Y. Kim, R.K. Agarwal, J.C.M. Schlachetzki, C.K. Glass, J. Lagerwall, D. Galasko, F.H. Gage, A. D’Alessandro, and J. Mertens#. .

Cell Metabolism, Aug 2022. 
 

‘Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients’
J. Mertens#, J.R. Herdy*, L. Traxler*, S.T. Schafer, J.C.M. Schlachetzki, L. Böhnke,  D.A. Reid, H. Lee, D. Zangwill,

D.P. Fernandes, R.K. Agarwal, R. Lucciola,  L. Zhou-Yang, L. Karbacher, F. Edenhofer, S. Stern, S. Horvath, A.C.M. Paquola,

C.K. Glass, S.H. Yuan, M. Ku, A. Szücs, L.S.B. Goldstein, D. Galasko, and F.H. Gage#
Cell Stem Cell, Apr 2021

 

'Metabolism navigates neural cell fate in development, aging and neurodegeneration'

L. Traxler, J. Lagerwall, S. Eichhorner, D. Stefanoni, A. D'Alessandro, and J. Mertens

Disease Models and Mechanisms, 2021

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'Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells' 

A. Soni, D. Klütsch, X. Hu, J. Houtman, N. Rund, A. McCloskey, J. Mertens, S. T. Schafer, H. Amin, T. Toda

Cells, 2021

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'Direct Conversion of Human Fibroblasts to Induced Neurons'
L. Zhou-Yang, S. Eichhorner, L. Karbacher, L. Böhnke, L. Traxler, and J. Mertens
Neural Reprogramming: Methods and Protocols, 2021

 

'One Big Step to a Neuron, Two Small Steps for miRNAs’

J. R. Herdy, L. Karbacher and J. Mertens#.

Cell Stem CellJan 2021

 

'When function follows form:  Nuclear compartment structure and the T epigenetic landscape of the aging neuron

J.C.M. Schlachetzki, T. Toda# and J. Mertens#.

Experimental Gerontology, Feb 2020

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'Next-generation disease modeling with direct conversion: a new path to old neurons’

L. Traxler, F. Edenhofer, and J. Mertens.

FEBS letters, Dec 2019

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‘Take the shortcut–direct conversion of somatic cells into induced neural stem cells and their biomedical applications’

A. Erharter, S. Rizzi, J. Mertens, and F. Edenhofer.

FEBS letters, Dec 2019

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‘Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons’

J. R. Herdy,  S.T. Schafer, Y. Kim, Z. Ansari, D. Zangwill, M. Ku, A.C.M. Paquola, H. Lee, J. Mertens#, and F.H. Gage#.

eLife, May 2019

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‘Human neurons to model aging: A dish best served old‘

L. Böhnke, L. Traxler, J. R. Herdy, and J. Mertens.

Drug Discovery Today: Disease Models, Feb 2019

 

‘Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons‘

S.T. Schafer, A.C.M. Paquola, S. Stern, D. Gosselin, M. Ku, M. Pena, T.J.M.  Kuret, M. Liyanage, A.A. Mansour, B.N. Jaeger, M.C. Marchetto, C.K. Glass, J. Mertens, and F.H. Gage.

Nature Neuroscience, Jan 2019

 

‘Aging in a dish: iPSC-derived and directly induced neurons for studying brain aging and age-related neurodegenerative diseases'

J. Mertens, D. Reid, S. Lau, Y. Kim, and F. H. Gage.

Annual Reviews Genetics , Sep 2018

 

‘Mitochondrial aging defects emerge in directly reprogrammed human neurons due to their metabolic profile ‘

Y. Kim, X. Zheng, Z. Ansari, M.C. Bunnell, J.R. Herdy, L. Traxler, H. Lee, A.C.M. Paquola, C. Blithikioti, M. Ku, J.C.M. Schlachetzki, J. Winkler, F. Edenhofer, C.K. Glass, A.A. Paucar, B.N. Jaeger, S. Pham, L. Boyer, B.C. Campbell, T. Hunter, J. Mertens#, F.H. Gage#.

Cell Reports, May 2018

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