Mertens Lab
‘Ignorance is bliss: Inhibition of proteomic stress sensing improves direct neuronal conversion’
Larissa Traxler, Oliver Borgogno, Jerome Mertens, Neuron, 2024.
‘Cellular reprogramming as a tool to model human aging in a dish’
Patricia R. Pitrez, Luis M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens & Lino Ferreira, Nature Communications, 2024.
‘Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy’
Cristina Marisol Castillo Bautista, Kristin Eismann, Marc Gentzel, Silvia Pelucchi, Jerome Mertens, Hannah E. Walters, Maximina H. Yun, Jared Sterneckert. Cells, 2023.
‘Neural cell state shifts and fate loss in ageing and age-related diseases’
Larissa Traxler, Raffaella Lucciola, Joseph R. Herdy, Jeffrey R. Jones, Jerome Mertens & Fred H. Gage, Nature Reviews Neurology, 2023.
‘Novel therapeutic approaches to target neurodegeneration’
Alerie G. de la Fuente, Silvia Pelucchi, Jerome Mertens, Monica Di Luca, Daniela Mauceri, Elena Marcello, British Journal of Pharmacology, 2023.
‘Increased Post-Mitotic Senescence in Aged Human Neurons is a Pathological Feature of Alzheimer’s Disease’
J. R. Herdy, L. Traxler, R.K. Agarwal, L. Karbacher, J.C.M. Schlachetzki, L. Boehnke, D. Zangwill, D. Galasko, C.K. Glass, J. Mertens# & F.H. Gage#.
Cell Stem Cell, Dec 2022.
‘Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion’
L. Böhnke, L. Zhou-Yang, S. Pelucchi, F. Kogler, D. Frantal, F. Schön, S. Lagerström, O. Borgogno, J. Baltazar, J.R. Herdy, S. Kittel-Schneider, M. Defrancesco, and J. Mertens#.
Cellular Reprogramming, Jul 2022.
‘Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease’
L. Traxler, J.R. Herdy, D. Stefanoni, S. Eichhorner, S. Pelucchi, A. Szücs, A. Santagostino, Y. Kim, R.K. Agarwal, J.C.M. Schlachetzki, C.K. Glass, J. Lagerwall, D. Galasko, F.H. Gage, A. D’Alessandro, and J. Mertens#. .
Cell Metabolism, Aug 2022.
‘Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients’
J. Mertens#, J.R. Herdy*, L. Traxler*, S.T. Schafer, J.C.M. Schlachetzki, L. Böhnke, D.A. Reid, H. Lee, D. Zangwill,
D.P. Fernandes, R.K. Agarwal, R. Lucciola, L. Zhou-Yang, L. Karbacher, F. Edenhofer, S. Stern, S. Horvath, A.C.M. Paquola,
C.K. Glass, S.H. Yuan, M. Ku, A. Szücs, L.S.B. Goldstein, D. Galasko, and F.H. Gage#
Cell Stem Cell, Apr 2021
‘Metabolism navigates neural cell fate in development, aging and neurodegeneration’
L. Traxler, J. Lagerwall, S. Eichhorner, D. Stefanoni, A. D'Alessandro, and J. Mertens
Disease Models and Mechanisms, 2021
‘Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells’
A. Soni, D. Klütsch, X. Hu, J. Houtman, N. Rund, A. McCloskey, J. Mertens, S. T. Schafer, H. Amin, T. Toda
Cells, 2021
‘Direct Conversion of Human Fibroblasts to Induced Neurons’
L. Zhou-Yang, S. Eichhorner, L. Karbacher, L. Böhnke, L. Traxler, and J. Mertens
Neural Reprogramming: Methods and Protocols, 2021
‘One Big Step to a Neuron, Two Small Steps for miRNAs’
J. R. Herdy, L. Karbacher and J. Mertens#.
Cell Stem Cell, Jan 2021
‘When function follows form: Nuclear compartment structure and the T epigenetic landscape of the aging neuron’
J.C.M. Schlachetzki, T. Toda# and J. Mertens#.
Experimental Gerontology, Feb 2020
‘Next-generation disease modeling with direct conversion: a new path to old neurons’
L. Traxler, F. Edenhofer, and J. Mertens.
FEBS letters, Dec 2019
‘Take the shortcut–direct conversion of somatic cells into induced neural stem cells and their biomedical applications’
A. Erharter, S. Rizzi, J. Mertens, and F. Edenhofer.
FEBS letters, Dec 2019
‘Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons’
J. R. Herdy, S.T. Schafer, Y. Kim, Z. Ansari, D. Zangwill, M. Ku, A.C.M. Paquola, H. Lee, J. Mertens#, and F.H. Gage#.
eLife, May 2019
‘Human neurons to model aging: A dish best served old’
L. Böhnke, L. Traxler, J. R. Herdy, and J. Mertens.
Drug Discovery Today: Disease Models, Feb 2019
‘Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons’
S.T. Schafer, A.C.M. Paquola, S. Stern, D. Gosselin, M. Ku, M. Pena, T.J.M. Kuret, M. Liyanage, A.A. Mansour, B.N. Jaeger, M.C. Marchetto, C.K. Glass, J. Mertens, and F.H. Gage.
Nature Neuroscience, Jan 2019
‘Aging in a dish: iPSC-derived and directly induced neurons for studying brain aging and age-related neurodegenerative diseases’
J. Mertens, D. Reid, S. Lau, Y. Kim, and F. H. Gage.
Annual Reviews Genetics , Sep 2018
‘Mitochondrial aging defects emerge in directly reprogrammed human neurons due to their metabolic profile’
Y. Kim, X. Zheng, Z. Ansari, M.C. Bunnell, J.R. Herdy, L. Traxler, H. Lee, A.C.M. Paquola, C. Blithikioti, M. Ku, J.C.M. Schlachetzki, J. Winkler, F. Edenhofer, C.K. Glass, A.A. Paucar, B.N. Jaeger, S. Pham, L. Boyer, B.C. Campbell, T. Hunter, J. Mertens#, F.H. Gage#.
Cell Reports, May 2018
Publications